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appendiceal colic
What is appendiceal colic?
 Unexplained recurrent abdominal pain (RAP) is a frequent symptom in childhood. Appendiceal colic is an often-unrecognized cause of chronic stomach pain in children,
Appendiceal colic, resulting from partial or intermittent appendiceal luminal obstruction, is probably the most common cause of chronic appendiceal pain. It's likely to be responsible for the pain leading to the bulk of negative appendectomies
 An organic cause is found in only 10% of cases.
 It is believed that in some children, partial luminal obstruction of the appendix by an inspissated cast of stool, may be one of the causes of this pain.
 The term appendiceal colic has been used to describe this syndrome.
 Causes of the luminal obstruction include
 fecaloma,
 fibrosis,
 lymphoid hyperplasia,
 or a foreign body.
 Untreated acute appendicitis may lead to scarring, which then partially blocks the lumen, causing appendiceal colic,
 Appendiceal colic may run in families.
 The severity, duration, and cycle of pain in appendiceal colic vary, depending on the nature of the luminal obstruction.
 In Dr. Stevenson's series of 210 patients, mean duration of pain was 11.2 months (range 1 day to 8 years). Mean age was 9.9 years (range 2-19), and 69% were female.
Appendiceal colic can be diagnosed easily in the office if the physician witnesses a painful episode. One trick is to precipitate the pain by feeding the patient just prior to the exam,
 The association with feeding is often remarkable. The patient may become pensive soon after ingesting any type of food or beverage and then quickly become visibly uncomfortable, writhing or even screaming with pain.
 The child may "rock" in a chair, curl up in a ball twisting from one side to the other, or move around holding the lower abdomen.
 Unlike biliary colic, which is exacerbated by fatty foods, appendiceal colic can be precipitated by carbohydrates and protein or anything that stimulates peristalsis, including hunger, anxiety, stress, and caffeine. Also unlike biliary colic, which may worsen 1-2 hours after ingesting a fatty meal, appendiceal colic usually starts within 5-20 minutes,
 During a painful episode, point tenderness documented on physical exam will identify the location of the appendix.
 Pressure on an appendix contracting against an obstruction will exacerbate the pain.
 Children who have been suffering from long-term undiagnosed appendiceal colic may have been told that the problem was psychological.
 They may have increasing absences from school with a drop in grades.
 Social life and athletic activity begin to wane, and apathy and lethargy may become pronounced.
 The child may lose weight because she has learned to not eat to avoid the pain.
 Since there is no visible inflammation in all cases and only a 12% prevalence of microscopic focal inflammation, imaging with ultrasound, computed tomography, or magnetic resonance -- which are most useful for documenting inflammation -- is of little use.
 Moreover, a fecaloma will look like stool on ultrasound; usually they have not become calcified.
 Instead, an upper gastrointestinal series with small-bowel follow-through and delayed films (12-24 hours) is more helpful.
 This series may document luminal filling defects and delayed emptying, which are important observations.
 Barium enema will also work, but it is an unpleasant exam, he told this newspaper.
 Routine blood work and urinalysis are virtually always normal in these patients but should be done if there is any doubt as to the diagnosis. In general, appendectomy is indicated if the history and physical are consistent with long-term or incapacitating appendiceal colic,
 Of the 210 patients diagnosed preoperatively with appendiceal colic, 205 (98%) had relief of the pain following elective appendectomy,
 Surgeons who recommended elective appendectomy for these patients require that certain criteria be met prior to operating on the patient.
 These include a history of abdominal pain for more than one month, three or more recurrent attacks of right lower quadrant (RLQ) abdominal pain and localized tenderness in the RLQ without signs of peritoneal irritation.
 Radiological findings at barium examination may support the clinical findings and consist of filling defects of the appendix, non-visualization of the appendix and retained barium.
Recurrent Abdominal Pain Syndrome
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Definition
Pain occurs at least once/month for at least 3 months
Ages 4 - 16 years (peaks at age 9 years)
Affects activity, school attendance
Epidemiology
Prevelance in school age children: 10%
Pathophysiology
Autonomic dysfunction with altered intestinal motility
Hyperalgesia and altered sensory pathways
Etiology
School Phobia (and related stresses) closely associated
These children often get lower grades than peers
Associated Conditions
Anorexia Nervosa
Symptoms
Nonspecific recurrent abdominal pain
Not related to meals or movement
No associated nausea, vomiting, or Dysuria
Signs
Well appearing child
Exam is often normal or mild abdominal tenderness
Signs: Red flags
Pain location distant from umbilicus
Pain that awakens child at night
Erythrocyte Sedimentation Rate (ESR) elevated
Weight loss
Labs (Limited and focused work-up)
Stool for Ova and Parasites for 3 samples
Giardia is common cause of recurrent abdominal pain
Urinalysis
Complete Blood Count (CBC)
Consider Erythrocyte Sedimentation Rate (ESR)
Radiology
Flat and upright abdominal XRay (KUB)
Consider RUQ Ultrasound
Consider pelvic ultrasound
Differential Diagnosis
Peptic Ulcer Disease
Carbohydrate intolerance
Appendiceal colic
Nephrolithiasis (Ureteropelvic junction obstruction)
Giardia
Blastocystis hominis
Hereditary Pancreatitis
Conversion reaction
Abdominal migraine
Epilepsy
Gynecologic disorder
Management
Avoid Medications
Emphasize the patient's response to pain
Involve the parents
Reassure that the problem is NOT life threatening
Be realistic and frank
Problem may persist for extended period of time
Treat suspected Constipation aggressively
Mineral Oil
Lactulose
Fleet Enema
Promote full activity and a sense of health
Encourage a well balanced diet
Encourage adequate hydration
Encourage adequate fiber intake
Maintain school attendance
Course
Usually resolves by age 20 years
Irritable Bowel Syndrome may develop
Pediatric Abdominal Pain Abdominal Pain in children
Pediatric Abdominal Pain Causes
Types
 Acute Abdominal Pain
 Characteristics
 Less than 4-6 weeks (subacute less than 12 weeks)
 Single episode, self limited and treatable
 Episodic localized pain, sharp, stabbing
 Common Causes
 Urinary tract disease
 Peptic Ulcer Disease
 Inflammatory Bowel Disease
 Gastroesophageal Reflux Disease
 Chronic Abdominal Pain
 Characteristics
 Three episodes over 3 months
 Continuous, dull, vague and diffuse abdominal pain
 Recurrent, Associated with debilitation
 Common Causes
 Constipation
 Lactose Intollerance
 Mittelschmerz
 Psychogenic (See Recurrent Abdominal Pain Syndrome)
 Secondary gain
 Sexual abuse
 School phobia
Red Flags
 Vomiting
Localized pain away from midline
 Altered bowel habits
 Growth disturbance
 Nocturnal episodes
 Radiation of pain
 Incontinence
 Systemic symptoms
 Family history
 Peptic Ulcer Disease
 Inflammatory Bowel Disease
History of Abdominal Pain
Timing
Onset of abdominal pain
Frequency, Duration and time of day
Location and radiation of abdominal pain
Intensity and character
Food associations
Milk or cheese
Spicy food
Caffeinated soda, tea
Exacerbating ammd relieving features
Associated symptoms
Fatigue
Syncope
Headache
Vomiting (before or after pain?)
Change in stool consistency or frquency
Relationships to activity and school
Which days of the weeks
Attempted therapies
Review of systems
 Genitourinary and gynecological symptoms
 Respiratory symptoms
 CNS symptoms
 Musculoskeletal symptoms
Past Medical History
 Surgical history
 Medications
 Major illnesses or hospitalizations
Family History
 Ethnic Background
 Migraine headache
 Seizure Disorder
 Gastroesophageal Reflux disease (GERD)
 Peptic Ulcer Disease (PUD)
 Inflammatory Bowel Disease (IBD)
 Irritable Bowel Syndrome (IBS)
 Pancreatitis
 Hepatitis
Social History
 HEADSS
 Home
 Education
 Activities
 Drug Use
 Suicidal ideation
 Sexual activity
 Death
 Divorce
 Serious illness
 Care providers
 Siblings
Physical Exam
 Perform in comfortable, non-threatening environment
 Growth
 Development
 Appearance
 Vital signs
 Comprehensive exam
 Abdominal exam
 Test rebound as "Jump on and off table"
 Avoid removing hand rapidly (loses patient trust)
 Rectal Exam necessary
Labs
Screening
 Complete Blood Count
 Erythrocyte Sedimentation Rate
 Urinalysis
 Urine Pregnancy Test (Urine HCG) when appropriate
 Liver Function Tests
 Amylase
 Lipase
 Consider additional testing
 Helicobacter pylori titer
 Ova and Parasites (e.g. Giardia)
 Hepatitis Serologies (A,B,C)
 Lead Ingestion
Radiology
 Flat and Upright abdominal XRay (KUB)
 Consider
 Barium Enema
 RUQ Ultrasound
 Pelvic Ultrasound
 Abdominal CT
 Skeletal Survey (assess physical abuse)
 Upper GI with small bowel follow through
 Upper endoscopy (EGD)
 Colonoscopy
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