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Specific Growth Curve Deviations
TABLE 1 Common Pathologic Etiologies of Weight Disorders
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Increased weight
Endocrine disorders
 Hypothyroidism
 Excess production of cortisol
 (Cushing's disease)
 Thalamic or pituitary disorders
Genetic disorders
 Down syndrome
 Prader-Willi syndrome
 Laurence-Moon syndrome
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Decreased weight
Undernutrition
Psychosocial deprivation
Hypothyroidism
Iron deficiency
Failure of a major organ system
(especially gastrointestinal, renal,
pulmonary or cardiovascular)
Lead intoxication
HIV infection
Immune deficiencies
Zinc deficiency
Inborn errors of metabolism
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HIV=human immunodeficiency virus.
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FIGURE 1
Algorithm for the evaluation of the patient with abnormal weight.
TABLE 2
Common Pathologic Etiologies of Height Disorders
Increased height
Excess production of growth hormone
Hyperthyroidism
Klinefelter's syndrome
Marfan syndrome
Homocystinuria
Decreased height
Growth hormone deficiency
Hypothyroidism
Chronic anemia
Chromosomal disorders (Turner's syndrome)
Failure of a major organ system (especially
gastrointestinal, renal, pulmonary or cardiovascular)
Skeletal dysplasia/rickets
Psychosocial deprivation
FIGURE 2
Algorithm for the evalution of the patient with abnormal height.
FIGURE 3
Algorithm for the evaluation of the patient with an abnormal head size.
TABLE 3
Common Pathologic Etiologies of Cranial Disorders
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Increased head size
Hydrocephalus
 Primary
 Secondary to associated disease of the central nervous system such as Arnold-Chiari malformation
Megalencephaly
 Primary
 Secondary to associated disease of the central nervous system such as neurofibromatosis or tuberous sclerosis.
 Secondary to metabolic storage disease such as Krabbe's disease
Decreased head size
Craniosynostosis
 Prenatal insult
 Maternal drug or alcohol abuse
 Maternal infection
 Complications of pregnancy/birth
Chromosome defects
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